Assay Detail
Binding
CHEMBL1646032
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Inhibition of tubulin polymerization
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.06 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9941 | — | — | 1 | 7.30 |
| CHEMBL1644876 | — | — | 1 | 6.16 |
| CHEMBL9859 | — | — | 1 | 5.75 |
| CHEMBL1644874 | — | — | 1 | 5.72 |
| CHEMBL1644878 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9941 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1644876 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL9859 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1644874 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1644878 | — | IC50 | = | 4100.0 | nM | 5.39 |