Assay Detail
Binding
CHEMBL1646129
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Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex by Lineweaver-Burk plot
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.00 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464538 | — | — | 1 | 7.30 |
| CHEMBL1642988 | — | — | 1 | 7.00 |
| CHEMBL1642977 | — | — | 1 | 6.70 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464538 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1642988 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1642977 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | Ki | = | 12100000.0 | nM | - |