Assay Detail
Binding
CHEMBL1646729
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Inhibition of human PI3K p110delta catalytic subunit by AlphaScreen assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.10 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428496 | WORTMANNIN | — | 1 | 8.40 |
| CHEMBL1645106 | — | — | 1 | 5.29 |
| CHEMBL1645108 | — | — | 1 | 5.19 |
| CHEMBL1645100 | — | — | 1 | 5.19 |
| CHEMBL1645110 | — | — | 1 | 5.17 |
| CHEMBL1645107 | — | — | 1 | 5.05 |
| CHEMBL1645095 | — | — | 1 | 4.96 |
| CHEMBL1645101 | — | — | 1 | 4.92 |
| CHEMBL1645102 | — | — | 1 | 4.75 |
| CHEMBL1645103 | — | — | 1 | 4.43 |
| CHEMBL1645094 | — | — | 1 | 4.39 |
| CHEMBL1645098 | — | — | 1 | 4.37 |
| CHEMBL58782 | — | — | 1 | 4.18 |
| CHEMBL1645099 | — | — | 1 | - |
| CHEMBL1645104 | — | — | 1 | - |
| CHEMBL1645105 | — | — | 1 | - |
| CHEMBL1645097 | — | — | 1 | - |
| CHEMBL1645096 | — | — | 1 | - |
| CHEMBL1645109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428496 | WORTMANNIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1645106 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1645108 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1645100 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1645110 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1645107 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1645095 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL1645101 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1645102 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1645103 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL1645094 | — | IC50 | = | 40800.0 | nM | 4.39 |
| CHEMBL1645098 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL58782 | — | IC50 | = | 65700.0 | nM | 4.18 |
| CHEMBL1645099 | — | IC50 | > | 83300.0 | nM | - |
| CHEMBL1645104 | — | IC50 | - | — | - | |
| CHEMBL1645105 | — | IC50 | - | — | - | |
| CHEMBL1645097 | — | IC50 | - | — | - | |
| CHEMBL1645096 | — | IC50 | > | 83300.0 | nM | - |
| CHEMBL1645109 | — | IC50 | - | — | - |