Assay Detail
Functional
CHEMBL1646836
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against X4 tropic HIV1 NL4.3 infected in human MT4 cells expressing CD4 and CXCR4 assessed as inhibition of virus-induced cytopathicity
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.47 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644082 | — | — | 1 | 9.51 |
| CHEMBL1644088 | — | — | 1 | 9.40 |
| CHEMBL1644081 | — | — | 1 | 9.00 |
| CHEMBL1644073 | — | — | 1 | 8.70 |
| CHEMBL1644080 | — | — | 1 | 8.38 |
| CHEMBL1644092 | — | — | 1 | 8.14 |
| CHEMBL1644089 | — | — | 1 | 8.10 |
| CHEMBL1644096 | — | — | 1 | 7.96 |
| CHEMBL1644078 | — | — | 1 | 7.92 |
| CHEMBL1644085 | — | — | 1 | 7.85 |
| CHEMBL1644074 | — | — | 1 | 7.77 |
| CHEMBL1644072 | — | — | 1 | 7.75 |
| CHEMBL1644075 | — | — | 1 | 7.70 |
| CHEMBL1093008 | — | — | 1 | 7.68 |
| CHEMBL1644094 | — | — | 1 | 7.68 |
| CHEMBL1644079 | — | — | 1 | 7.66 |
| CHEMBL1644076 | — | — | 1 | 7.16 |
| CHEMBL1644095 | — | — | 1 | 6.99 |
| CHEMBL1644077 | — | — | 1 | 6.98 |
| CHEMBL1644071 | — | — | 1 | 6.98 |
| CHEMBL1644083 | — | — | 1 | 6.91 |
| CHEMBL1644070 | — | — | 1 | 6.78 |
| CHEMBL1644086 | — | — | 1 | 5.61 |
| CHEMBL1644091 | — | — | 1 | 5.55 |
| CHEMBL1644087 | — | — | 1 | 5.45 |
| CHEMBL1644093 | — | — | 1 | 4.70 |
| CHEMBL1644090 | — | — | 1 | - |
| CHEMBL1644084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644082 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1644088 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1644081 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL1644073 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1644080 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1644092 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1644089 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1644096 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL1644078 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1644085 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1644074 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1644072 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1644075 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1093008 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1644094 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1644079 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1644076 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1644095 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL1644077 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL1644071 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL1644083 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL1644070 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1644086 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL1644091 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL1644087 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL1644093 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL1644090 | — | IC50 | > | 1160.0 | nM | - |
| CHEMBL1644084 | — | IC50 | > | 1230.0 | nM | - |