Assay Detail
Functional
CHEMBL1646948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CRTH2 in human eosinophil assessed as effect of cellular shape change by EOS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azaindoles as potent CRTH2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.52 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1641811 | — | — | 1 | 8.92 |
| CHEMBL1641816 | — | — | 1 | 8.92 |
| CHEMBL561132 | MK-7246 | 1.0 | 1 | 8.66 |
| CHEMBL1641813 | — | — | 1 | 8.64 |
| CHEMBL1641815 | — | — | 1 | 8.62 |
| CHEMBL1641814 | — | — | 1 | 8.51 |
| CHEMBL1641809 | — | — | 1 | 8.48 |
| CHEMBL1641817 | — | — | 1 | 8.47 |
| CHEMBL1641808 | — | — | 1 | 8.15 |
| CHEMBL1641810 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1641811 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1641816 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL561132 | MK-7246 | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1641813 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1641815 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1641814 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1641809 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1641817 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1641808 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1641810 | — | IC50 | = | 15.8 | nM | 7.80 |