Assay Detail
ADMET
CHEMBL1647134
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Inhibition of CYP2C19
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.50 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 6.51 |
| CHEMBL1642913 | — | — | 1 | 5.79 |
| CHEMBL1642907 | — | — | 1 | 5.66 |
| CHEMBL1642912 | — | — | 1 | 5.42 |
| CHEMBL1642895 | — | — | 1 | 5.28 |
| CHEMBL1642908 | — | — | 1 | 5.22 |
| CHEMBL1642906 | — | — | 1 | 5.11 |
| CHEMBL1642897 | — | — | 1 | 4.99 |
| CHEMBL1642914 | — | — | 1 | - |
| CHEMBL1642915 | — | — | 1 | - |
| CHEMBL1642916 | — | — | 1 | - |
| CHEMBL1642917 | — | — | 1 | - |
| CHEMBL1642894 | — | — | 1 | - |
| CHEMBL1642896 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL809 | SERTRALINE | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1642913 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL1642907 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL1642912 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL1642895 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL1642908 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL1642906 | — | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL1642897 | — | IC50 | = | 10150.0 | nM | 4.99 |
| CHEMBL1642914 | — | IC50 | - | — | - | |
| CHEMBL1642915 | — | IC50 | - | — | - | |
| CHEMBL1642916 | — | IC50 | - | — | - | |
| CHEMBL1642917 | — | IC50 | - | — | - | |
| CHEMBL1642894 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1642896 | — | IC50 | > | 25000.0 | nM | - |