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Assay Detail

CHEMBL1647196

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxytosis after 24 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type HT-22
Confidence 1 — Organism
Curated By Autocuration

Target

HT-22 (CHEMBL614316)
Type CELL-LINE
Organism Mus musculus

Publication

New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription.
Villalonga-Barber C, Meligova AK, Alexi X, Steele BR, Kouzinos CE, Screttas CG, Katsanou ES, Micha-Screttas M, Alexis MN.
Bioorg Med Chem (2011) 19 : 339 -351
PubMed 21129978 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 6.59 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1641658 1 7.92
CHEMBL1641654 1 7.52
CHEMBL1641656 1 7.35
CHEMBL1641657 1 7.10
CHEMBL1641659 1 7.04
CHEMBL1641660 1 6.92
CHEMBL1641666 1 6.59
CHEMBL1641663 1 6.40
CHEMBL1641665 1 6.39
CHEMBL1641653 1 6.37
CHEMBL1641655 1 6.32
CHEMBL1641664 1 6.21
CHEMBL1641662 1 5.97
CHEMBL1641661 1 5.48
CHEMBL165 RESVERATROL 3.0 1 5.33
CHEMBL1641667 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1641658 EC50 = 12.0 nM 7.92
CHEMBL1641654 EC50 = 30.0 nM 7.52
CHEMBL1641656 EC50 = 45.0 nM 7.35
CHEMBL1641657 EC50 = 79.0 nM 7.10
CHEMBL1641659 EC50 = 91.0 nM 7.04
CHEMBL1641660 EC50 = 119.0 nM 6.92
CHEMBL1641666 EC50 = 258.0 nM 6.59
CHEMBL1641663 EC50 = 399.0 nM 6.40
CHEMBL1641665 EC50 = 410.0 nM 6.39
CHEMBL1641653 EC50 = 432.0 nM 6.37
CHEMBL1641655 EC50 = 484.0 nM 6.32
CHEMBL1641664 EC50 = 621.0 nM 6.21
CHEMBL1641662 EC50 = 1060.0 nM 5.97
CHEMBL1641661 EC50 = 3310.0 nM 5.48
CHEMBL165 RESVERATROL EC50 = 4667.0 nM 5.33
CHEMBL1641667 EC50 > 10000.0 nM -