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Target Snapshot

CHEMBL614316 Target Snapshot

HT-22 · CELL-LINE · Mus musculus

1,598Compounds
662Assays
8Approved Drugs
602.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HT-22 as ChEMBL target CHEMBL614316. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HT-22
CELL-LINE · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL614316
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HT-22 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHT-22
UniProt AccessionN/A

HT-22

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as HT-22.

Review nameHT-22
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

8
Approved
7
Phase III
4
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50169.0
EC50433.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1951841 8.3 EC50 5.0 Preclinical
CHEMBL1951865 8.15 EC50 7.0 Preclinical
CHEMBL1333512 8.11 EC50 7.7 Preclinical
CHEMBL1641658 7.92 EC50 12.0 Preclinical
CHEMBL1951842 7.82 EC50 15.0 Preclinical
CHEMBL1951830 7.7 EC50 20.0 Preclinical
CHEMBL1951836 7.7 EC50 20.0 Preclinical
CHEMBL1951856 7.7 EC50 20.0 Preclinical
CHEMBL1951857 7.7 EC50 20.0 Preclinical
CHEMBL2387144 7.7 EC50 20.0 Preclinical
Distribution

pChEMBL Value Distribution

95
5.0
73
5.5
74
6.0
29
6.5
22
7.0
10
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

QUIZARTINIB
CHEMBL576982
Approved 2023
MIDOSTAURIN
CHEMBL608533
Approved 2017
Assay Landscape

Assay Landscape

662
Total Assays
303
Tested Compounds
3
Assay Types
Functional — 530 assays, 303 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 530 303 5.8
ADME — 72 assays, 68 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 72 68 5.0
Toxicity — 60 assays, 70 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 60 70 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine