Compound Detail
CHEMBL1951865
CMS-121 Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL1951865 |
| Name | CMS-121 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | OMHNVUCFPJJLKD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
2
Known Names
1
Indications
Molecular Properties
321.4
MW (Da)
4.63
ALogP
4
HBA
2
HBD
62.6
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Alzheimer Disease
Activity Summary
EC50 1 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HT-22 CHEMBL614316 | EC50 | 8.15 | 8.15 | 7.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HT-22 | EC50 | = | 7.0 | nM | 8.15 | Neuroprotective activity in mouse HT22 cells assessed as reduction in IAA-induce... | 22192055 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22192055 | 10.1021/jm2012563 | HT-22 | 3 |
| 22192055 | 10.1021/jm2012563 | PC-12 | 1 |
| 22192055 | 10.1021/jm2012563 | N9 | 1 |
| 22192055 | 10.1021/jm2012563 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine