Assay Detail
Functional
CHEMBL1952431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity in mouse HT22 cells assessed as reduction in IAA-induced ischemia after 24 hrs by MTT assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HT-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemical modification of the multitarget neuroprotective compound fisetin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 55 | 6.99 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1951841 | — | — | 1 | 8.30 |
| CHEMBL1951865 | CMS-121 | 1.0 | 1 | 8.15 |
| CHEMBL1951842 | — | — | 1 | 7.82 |
| CHEMBL1951830 | — | — | 1 | 7.70 |
| CHEMBL1951836 | — | — | 1 | 7.70 |
| CHEMBL1951856 | — | — | 1 | 7.70 |
| CHEMBL1951857 | — | — | 1 | 7.70 |
| CHEMBL1951825 | — | — | 1 | 7.52 |
| CHEMBL1951827 | — | — | 1 | 7.40 |
| CHEMBL1951829 | — | — | 1 | 7.40 |
| CHEMBL1951837 | — | — | 1 | 7.40 |
| CHEMBL1951853 | — | — | 1 | 7.40 |
| CHEMBL1951843 | — | — | 1 | 7.30 |
| CHEMBL1951849 | — | — | 1 | 7.30 |
| CHEMBL1951863 | — | — | 1 | 7.30 |
| CHEMBL1951860 | — | — | 1 | 7.22 |
| CHEMBL1951833 | — | — | 1 | 7.16 |
| CHEMBL1482959 | — | — | 1 | 7.10 |
| CHEMBL1951826 | — | — | 1 | 7.10 |
| CHEMBL1951846 | — | — | 1 | 7.10 |
| CHEMBL1951821 | — | — | 1 | 7.05 |
| CHEMBL1951840 | — | — | 1 | 7.05 |
| CHEMBL1951824 | — | — | 1 | 6.77 |
| CHEMBL1951834 | — | — | 1 | 6.70 |
| CHEMBL1951850 | — | — | 1 | 6.70 |
| CHEMBL1951859 | — | — | 1 | 6.68 |
| CHEMBL1951839 | — | — | 1 | 6.60 |
| CHEMBL1951822 | — | — | 1 | 6.60 |
| CHEMBL1951818 | — | — | 1 | 6.60 |
| CHEMBL1951819 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1951841 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1951865 | CMS-121 | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1951842 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1951830 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1951836 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1951856 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1951857 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1951825 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1951827 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1951829 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1951837 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1951853 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1951863 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1951849 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1951843 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1951860 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1951833 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1482959 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1951826 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1951846 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1951821 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1951840 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1951824 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1951834 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1951850 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1951859 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1951822 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1951818 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1951839 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1951819 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL122701 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1951816 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1951817 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1951823 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1951847 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1951854 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1951864 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL279335 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL31574 | FISETIN | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1951844 | — | EC50 | - | — | - | |
| CHEMBL1951862 | — | EC50 | - | — | - | |
| CHEMBL1951845 | — | EC50 | - | — | - | |
| CHEMBL1951848 | — | EC50 | - | — | - | |
| CHEMBL1951851 | — | EC50 | - | — | - | |
| CHEMBL1951852 | — | EC50 | - | — | - | |
| CHEMBL1951855 | — | EC50 | - | — | - | |
| CHEMBL1951861 | — | EC50 | - | — | - | |
| CHEMBL1951820 | — | EC50 | - | — | - | |
| CHEMBL1951815 | — | EC50 | - | — | - | |
| CHEMBL1951858 | — | EC50 | > | 500.0 | nM | - |