Assay Detail
Functional
CHEMBL1647393
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Antiproliferative activity against human NCI-N87 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-N87 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.52 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248108 | — | — | 1 | 7.46 |
| CHEMBL1645474 | — | — | 1 | 7.30 |
| CHEMBL1645473 | — | — | 1 | 7.22 |
| CHEMBL246284 | — | — | 1 | 7.08 |
| CHEMBL1645466 | — | — | 1 | 6.92 |
| CHEMBL1645476 | — | — | 1 | 6.92 |
| CHEMBL1645467 | — | — | 1 | 6.85 |
| CHEMBL1645470 | — | — | 1 | 6.85 |
| CHEMBL1645472 | — | — | 1 | 6.55 |
| CHEMBL1645462 | AC-480 | 1.0 | 1 | 6.35 |
| CHEMBL1645471 | — | — | 1 | 6.10 |
| CHEMBL1645477 | — | — | 1 | 5.92 |
| CHEMBL1645469 | — | — | 1 | 5.48 |
| CHEMBL1645475 | — | — | 1 | 5.47 |
| CHEMBL1645465 | — | — | 1 | 5.36 |
| CHEMBL1645463 | — | — | 1 | - |
| CHEMBL1645464 | — | — | 1 | - |
| CHEMBL1645468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248108 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1645474 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1645473 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL246284 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1645466 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1645476 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1645467 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1645470 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1645472 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1645462 | AC-480 | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1645471 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1645477 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1645469 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1645475 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL1645465 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1645463 | — | IC50 | - | — | - | |
| CHEMBL1645464 | — | IC50 | - | — | - | |
| CHEMBL1645468 | — | IC50 | - | — | - |