Assay Detail
Binding
CHEMBL1647472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]RTX from rat TRV1 expressed in CHO cells by competitive binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL5102) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Receptor activity and conformational analysis of 5'-halogenated resiniferatoxin analogs as TRPV1 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.20 | 10.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | 3.0 | 1 | 10.37 |
| CHEMBL1644419 | — | — | 1 | 9.89 |
| CHEMBL1644416 | — | — | 1 | 9.77 |
| CHEMBL1644414 | — | — | 1 | 9.59 |
| CHEMBL1644417 | — | — | 1 | 9.52 |
| CHEMBL1644413 | — | — | 1 | 9.21 |
| CHEMBL1644420 | — | — | 1 | 9.15 |
| CHEMBL1644421 | — | — | 1 | 9.07 |
| CHEMBL1644415 | — | — | 1 | 8.99 |
| CHEMBL1644422 | — | — | 1 | 8.70 |
| CHEMBL1644418 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | Ki | = | 0.043 | nM | 10.37 |
| CHEMBL1644419 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL1644416 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL1644414 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL1644417 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1644413 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL1644420 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1644421 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL1644415 | — | Ki | = | 1.03 | nM | 8.99 |
| CHEMBL1644422 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL1644418 | — | Ki | = | 110.0 | nM | 6.96 |