Assay Detail
Functional
CHEMBL1647720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human PMNC cells assessed as inhibition of fMLP-induced NOX-dependent ROS production up to 50 uM
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PMNC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.81 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365739 | DIPHENYLENEIODONIUM | — | 1 | 6.52 |
| CHEMBL1644792 | ZHANKUIC ACID A METHYL ESTER | — | 1 | 5.08 |
| CHEMBL1641969 | CAMPHORATIN F | — | 1 | 4.95 |
| CHEMBL1641973 | CAMPHORATIN J | — | 1 | 4.80 |
| CHEMBL1641980 | — | — | 1 | 4.79 |
| CHEMBL1641972 | CAMPHORATIN I | — | 1 | 4.76 |
| CHEMBL1644795 | METHYL ANTCINATE H | — | 1 | 4.74 |
| CHEMBL434750 | ERGOSTEROL PEROXIDE | — | 1 | 4.69 |
| CHEMBL426367 | EBURICOL | — | 1 | 4.66 |
| CHEMBL1644789 | ZHANKUIC ACID A | — | 1 | 4.66 |
| CHEMBL1641967 | CAMPHORATIN D | — | 1 | 4.65 |
| CHEMBL1232562 | ERGOSTEROL | — | 1 | 4.55 |
| CHEMBL1644793 | ANTCIN A | — | 1 | 4.54 |
| CHEMBL1641965 | CAMPHORATIN B | — | 1 | 4.49 |
| CHEMBL1644794 | ANTCIN K | — | 1 | 4.33 |
| CHEMBL1644791 | ZHANKUIC ACID C | — | 1 | - |
| CHEMBL1644790 | ZHANKUIC ACID B | — | 1 | - |
| CHEMBL7890 | L-NAME | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365739 | DIPHENYLENEIODONIUM | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1644792 | ZHANKUIC ACID A METHYL ESTER | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1641969 | CAMPHORATIN F | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1641973 | CAMPHORATIN J | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1641980 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL1641972 | CAMPHORATIN I | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1644795 | METHYL ANTCINATE H | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL434750 | ERGOSTEROL PEROXIDE | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL426367 | EBURICOL | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL1644789 | ZHANKUIC ACID A | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL1641967 | CAMPHORATIN D | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL1232562 | ERGOSTEROL | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL1644793 | ANTCIN A | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL1641965 | CAMPHORATIN B | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL1644794 | ANTCIN K | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL1644791 | ZHANKUIC ACID C | IC50 | - | — | - | |
| CHEMBL1644790 | ZHANKUIC ACID B | IC50 | - | — | - | |
| CHEMBL7890 | L-NAME | IC50 | - | — | - |