Assay Detail

CHEMBL1647723

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Vasorelaxant activity in Wistar rat endothelium-intact thoracic aortic ring assessed as inhibition of noradrenaline-induced contraction treated after noradrenaline challenge measured after 60 mins

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Aorta (CHEMBL613606) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Aorta (CHEMBL613606) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Aorta

CHEMBL613606

Anchored from Assay target.

Protein identity Aorta

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Aorta
Confidence	1 — Organism
Curated By	Autocuration

Target

Aorta (CHEMBL613606) ↗

Type	TISSUE
Organism	Rattus norvegicus

Publication

Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches.

Torres-Piedra M, Figueroa M, Hernández-Abreu O, Ibarra-Barajas M, Navarrete-Vázquez G, Estrada-Soto S, Estrada-Soto S.
Bioorg Med Chem (2011) 19 : 542 -546
PubMed 21129983 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	9	4.73	6.10
Inhibition	6	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL14	CARBACHOL	4.0	1	6.10
CHEMBL138649	6-HYDROXYFLAVONE	—	2	4.68
CHEMBL276915	7-HYDROXYFLAVONE	—	2	4.42
CHEMBL275638	FLAVONE	2.0	2	4.34
CHEMBL117	CHRYSIN	—	2	4.12
CHEMBL294009	FLAVONOL	—	2	-
CHEMBL50	QUERCETIN	3.0	2	-
CHEMBL9352	NARINGENIN	—	1	-
CHEMBL193	NIFEDIPINE	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL14	CARBACHOL	IC50	=	790.0	nM	6.10
CHEMBL138649	6-HYDROXYFLAVONE	IC50	=	20800.0	nM	4.68
CHEMBL276915	7-HYDROXYFLAVONE	IC50	=	37800.0	nM	4.42
CHEMBL275638	FLAVONE	IC50	=	46000.0	nM	4.34
CHEMBL117	CHRYSIN	IC50	=	75700.0	nM	4.12
CHEMBL294009	FLAVONOL	IC50	=	203600.0	nM	-
CHEMBL50	QUERCETIN	IC50	=	162500.0	nM	-
CHEMBL9352	NARINGENIN	IC50		-	—	-
CHEMBL193	NIFEDIPINE	IC50		-	—	-
CHEMBL275638	FLAVONE	Inhibition		-	%	-
CHEMBL294009	FLAVONOL	Inhibition		-	%	-
CHEMBL138649	6-HYDROXYFLAVONE	Inhibition		-	%	-
CHEMBL276915	7-HYDROXYFLAVONE	Inhibition		-	%	-
CHEMBL117	CHRYSIN	Inhibition		-	%	-
CHEMBL50	QUERCETIN	Inhibition		-	%	-