Assay Detail
Binding
CHEMBL1648149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.26 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570753 | — | — | 1 | 5.66 |
| CHEMBL251958 | FLAVOKAWAIN C | — | 1 | 5.51 |
| CHEMBL570526 | KUWANON R | — | 1 | 5.50 |
| CHEMBL104255 | FLAVOKAWAIN B | — | 1 | 5.48 |
| CHEMBL570972 | — | — | 1 | 5.44 |
| CHEMBL2368640 | — | — | 1 | 5.42 |
| CHEMBL570475 | KUWANON J | — | 1 | 5.39 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | 5.32 |
| CHEMBL570609 | KUWANON V | — | 1 | 5.08 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.02 |
| CHEMBL570248 | — | — | 1 | 5.00 |
| CHEMBL243829 | FLAVOKAWAIN A | — | 1 | 4.96 |
| CHEMBL397256 | — | — | 1 | 4.94 |
| CHEMBL572289 | — | — | 1 | 4.92 |
| CHEMBL1644613 | — | — | 1 | - |
| CHEMBL572323 | — | — | 1 | - |
| CHEMBL571085 | — | — | 1 | - |
| CHEMBL7747 | 4-HYDROXYCHALCONE | — | 1 | - |
| CHEMBL571313 | — | — | 1 | - |
| CHEMBL571956 | — | — | 1 | - |
| CHEMBL145495 | — | — | 1 | - |
| CHEMBL450678 | — | — | 1 | - |
| CHEMBL128000 | BUTEIN | — | 1 | - |
| CHEMBL147067 | — | — | 1 | - |
| CHEMBL7976 | CHALCONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570753 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL251958 | FLAVOKAWAIN C | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL570526 | KUWANON R | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL104255 | FLAVOKAWAIN B | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL570972 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2368640 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL570475 | KUWANON J | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL570609 | KUWANON V | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL140 | CURCUMIN | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL570248 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL243829 | FLAVOKAWAIN A | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL397256 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL572289 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1644613 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL572323 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL571085 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | > | 20000.0 | nM | - |
| CHEMBL571313 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL571956 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL145495 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL450678 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL128000 | BUTEIN | IC50 | > | 20000.0 | nM | - |
| CHEMBL147067 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL7976 | CHALCONE | IC50 | > | 20000.0 | nM | - |