Assay Detail
Binding
CHEMBL1648161
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Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.00 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437747 | — | — | 1 | 8.80 |
| CHEMBL1644637 | — | — | 1 | 7.85 |
| CHEMBL1644639 | — | — | 1 | 7.80 |
| CHEMBL1644638 | — | — | 1 | 7.66 |
| CHEMBL1644618 | — | — | 1 | 7.62 |
| CHEMBL1644646 | — | — | 1 | 7.62 |
| CHEMBL1644642 | — | — | 1 | 7.54 |
| CHEMBL1644619 | — | — | 1 | 7.50 |
| CHEMBL1644645 | — | — | 1 | 7.44 |
| CHEMBL1644625 | — | — | 1 | 7.40 |
| CHEMBL1644635 | — | — | 1 | 7.27 |
| CHEMBL1644615 | — | — | 1 | 7.27 |
| CHEMBL1644624 | — | — | 1 | 7.21 |
| CHEMBL1644622 | — | — | 1 | 7.16 |
| CHEMBL1644632 | — | — | 1 | 7.16 |
| CHEMBL1644620 | — | — | 1 | 7.07 |
| CHEMBL1644640 | — | — | 1 | 7.04 |
| CHEMBL1644636 | — | — | 1 | 7.03 |
| CHEMBL1644641 | — | — | 1 | 7.00 |
| CHEMBL1644630 | — | — | 1 | 6.92 |
| CHEMBL1644621 | — | — | 1 | 6.89 |
| CHEMBL1644623 | — | — | 1 | 6.89 |
| CHEMBL1644643 | — | — | 1 | 6.80 |
| CHEMBL1644627 | — | — | 1 | 6.68 |
| CHEMBL1644626 | — | — | 1 | 6.60 |
| CHEMBL1644644 | — | — | 1 | 6.55 |
| CHEMBL1644629 | — | — | 1 | 6.39 |
| CHEMBL1644634 | — | — | 1 | 6.37 |
| CHEMBL1644631 | — | — | 1 | 6.23 |
| CHEMBL1644633 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437747 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1644637 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1644639 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1644638 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1644618 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1644646 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1644642 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1644619 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1644645 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1644625 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1644635 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1644615 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1644624 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1644622 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1644632 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1644620 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1644640 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1644636 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1644641 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1644630 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1644621 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1644623 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1644643 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1644627 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1644626 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1644644 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1644629 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1644634 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1644631 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1644633 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1644628 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1644617 | — | IC50 | = | 16000.0 | nM | 4.80 |