Assay Detail
Functional
CHEMBL1648263
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Antiviral activity against VSV-G protein pseudotyped HIV1 luciferase reporter virus in mixture of human HeLa/JC53 cells assessed as luminescence after 48 hrs
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa/JC53 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.65 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 9.15 |
| CHEMBL1645571 | — | — | 1 | 9.05 |
| CHEMBL1645582 | — | — | 1 | 8.85 |
| CHEMBL1645569 | — | — | 1 | 8.85 |
| CHEMBL1645568 | — | — | 1 | 8.57 |
| CHEMBL1645581 | — | — | 1 | 8.34 |
| CHEMBL1645567 | — | — | 1 | 8.23 |
| CHEMBL1645583 | — | — | 1 | 8.12 |
| CHEMBL1645566 | — | — | 1 | 8.07 |
| CHEMBL1645572 | — | — | 1 | 8.00 |
| CHEMBL1645558 | — | — | 1 | 7.96 |
| CHEMBL1645570 | — | — | 1 | 7.80 |
| CHEMBL1645565 | — | — | 1 | 7.70 |
| CHEMBL1641640 | — | — | 1 | 7.40 |
| CHEMBL1645559 | — | — | 1 | 7.27 |
| CHEMBL1645560 | — | — | 1 | 7.19 |
| CHEMBL1645580 | — | — | 1 | 7.09 |
| CHEMBL1645577 | — | — | 1 | 7.01 |
| CHEMBL1645578 | — | — | 1 | 6.82 |
| CHEMBL1645564 | — | — | 1 | 6.75 |
| CHEMBL1645563 | — | — | 1 | 6.75 |
| CHEMBL1645562 | — | — | 1 | 6.54 |
| CHEMBL1645576 | — | — | 1 | 6.31 |
| CHEMBL1645579 | — | — | 1 | 5.84 |
| CHEMBL1645575 | — | — | 1 | - |
| CHEMBL1645574 | — | — | 1 | - |
| CHEMBL1645573 | — | — | 1 | - |
| CHEMBL1645561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1645571 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1645582 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1645569 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1645568 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1645581 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1645567 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1645583 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1645566 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL1645572 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL1645558 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1645570 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1645565 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1641640 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1645559 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1645560 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1645580 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1645577 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1645578 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1645564 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1645563 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL1645562 | — | EC50 | = | 291.0 | nM | 6.54 |
| CHEMBL1645576 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1645579 | — | EC50 | = | 1458.0 | nM | 5.84 |
| CHEMBL1645575 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL1645574 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL1645573 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL1645561 | — | EC50 | > | 2500.0 | nM | - |