Assay Detail
Functional
CHEMBL1648264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against VSV-G protein pseudotyped HIV1 luciferase reporter virus in mixture of human HeLa/JC53 cells assessed as luminescence after 48 hrs in presence of 40% human serum
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa/JC53 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.70 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1645571 | — | — | 1 | 8.62 |
| CHEMBL1645569 | — | — | 1 | 7.72 |
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 7.44 |
| CHEMBL1645572 | — | — | 1 | 7.41 |
| CHEMBL1645583 | — | — | 1 | 7.38 |
| CHEMBL1645582 | — | — | 1 | 7.28 |
| CHEMBL1645566 | — | — | 1 | 7.21 |
| CHEMBL1645567 | — | — | 1 | 6.89 |
| CHEMBL1645558 | — | — | 1 | 6.87 |
| CHEMBL1645581 | — | — | 1 | 6.86 |
| CHEMBL1645570 | — | — | 1 | 6.71 |
| CHEMBL1645568 | — | — | 1 | 6.70 |
| CHEMBL1645565 | — | — | 1 | 6.61 |
| CHEMBL1645580 | — | — | 1 | 6.55 |
| CHEMBL1641640 | — | — | 1 | 6.51 |
| CHEMBL1645578 | — | — | 1 | 6.42 |
| CHEMBL1645577 | — | — | 1 | 6.38 |
| CHEMBL1645559 | — | — | 1 | 6.37 |
| CHEMBL1645564 | — | — | 1 | 5.99 |
| CHEMBL1645563 | — | — | 1 | 5.98 |
| CHEMBL1645579 | — | — | 1 | 5.80 |
| CHEMBL1645562 | — | — | 1 | 5.75 |
| CHEMBL1645560 | — | — | 1 | 5.71 |
| CHEMBL1645576 | — | — | 1 | 5.57 |
| CHEMBL1645575 | — | — | 1 | - |
| CHEMBL1645574 | — | — | 1 | - |
| CHEMBL1645573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1645571 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1645569 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1645572 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1645583 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1645582 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1645566 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1645567 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL1645558 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL1645581 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL1645570 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL1645568 | — | EC50 | = | 199.0 | nM | 6.70 |
| CHEMBL1645565 | — | EC50 | = | 245.0 | nM | 6.61 |
| CHEMBL1645580 | — | EC50 | = | 283.0 | nM | 6.55 |
| CHEMBL1641640 | — | EC50 | = | 307.0 | nM | 6.51 |
| CHEMBL1645578 | — | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL1645577 | — | EC50 | = | 421.0 | nM | 6.38 |
| CHEMBL1645559 | — | EC50 | = | 425.0 | nM | 6.37 |
| CHEMBL1645564 | — | EC50 | = | 1015.0 | nM | 5.99 |
| CHEMBL1645563 | — | EC50 | = | 1049.0 | nM | 5.98 |
| CHEMBL1645579 | — | EC50 | = | 1593.0 | nM | 5.80 |
| CHEMBL1645562 | — | EC50 | = | 1772.0 | nM | 5.75 |
| CHEMBL1645560 | — | EC50 | = | 1937.0 | nM | 5.71 |
| CHEMBL1645576 | — | EC50 | = | 2684.0 | nM | 5.57 |
| CHEMBL1645575 | — | EC50 | - | — | - | |
| CHEMBL1645574 | — | EC50 | - | — | - | |
| CHEMBL1645573 | — | EC50 | - | — | - |