Assay Detail
Binding
CHEMBL1648829
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Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437747 | — | — | 1 | 8.40 |
| CHEMBL1644632 | — | — | 1 | - |
| CHEMBL1644628 | — | — | 1 | - |
| CHEMBL1644617 | — | — | 1 | - |
| CHEMBL1644618 | — | — | 1 | - |
| CHEMBL1644619 | — | — | 1 | - |
| CHEMBL1644620 | — | — | 1 | - |
| CHEMBL1644621 | — | — | 1 | - |
| CHEMBL1644622 | — | — | 1 | - |
| CHEMBL1644623 | — | — | 1 | - |
| CHEMBL1644624 | — | — | 1 | - |
| CHEMBL1644625 | — | — | 1 | - |
| CHEMBL1644626 | — | — | 1 | - |
| CHEMBL1644627 | — | — | 1 | - |
| CHEMBL1644629 | — | — | 1 | - |
| CHEMBL1644631 | — | — | 1 | - |
| CHEMBL1644633 | — | — | 1 | - |
| CHEMBL1644634 | — | — | 1 | - |
| CHEMBL1644635 | — | — | 1 | - |
| CHEMBL1644636 | — | — | 1 | - |
| CHEMBL1644638 | — | — | 1 | - |
| CHEMBL1644639 | — | — | 1 | - |
| CHEMBL1644640 | — | — | 1 | - |
| CHEMBL1644641 | — | — | 1 | - |
| CHEMBL1644615 | — | — | 1 | - |
| CHEMBL1644642 | — | — | 1 | - |
| CHEMBL1644643 | — | — | 1 | - |
| CHEMBL1644646 | — | — | 1 | - |
| CHEMBL1644630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437747 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1644632 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644628 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1644617 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644618 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644619 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644620 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644621 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644622 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644623 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644624 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644625 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644626 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644627 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644629 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644631 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644633 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644634 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644635 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644636 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644638 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644639 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644640 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644641 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644615 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644642 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644643 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644646 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1644630 | — | IC50 | > | 50000.0 | nM | - |