Assay Detail
Functional
CHEMBL1648832
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Neuroprotective activity in human cortical neurons assessed as inhibition of amyloid-beta-induced toxicity after 2 to 3 days
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cortical neurone |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.92 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644642 | — | — | 1 | 4.92 |
| CHEMBL1644618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644642 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1644618 | — | EC50 | > | 50000.0 | nM | - |