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Assay Detail

CHEMBL1648934

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Binding
Inhibition of rat liver xanthine oxidase by spectrophotometry
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Xanthine dehydrogenase/oxidase (CHEMBL1075246)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives.
Sathisha KR, Khanum SA, Chandra JN, Ayisha F, Balaji S, Marathe GK, Gopal S, Rangappa KS.
Bioorg Med Chem (2011) 19 : 211 -220
PubMed 21163661 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.01 6.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1644702 1 6.54
CHEMBL1644704 1 6.44
CHEMBL1644703 1 6.38
CHEMBL1641632 1 6.35
CHEMBL1644719 1 6.26
CHEMBL1644713 1 6.23
CHEMBL1644706 1 6.21
CHEMBL1467 ALLOPURINOL 4.0 1 6.12
CHEMBL1644715 1 5.99
CHEMBL1644707 1 5.97
CHEMBL1644712 1 5.75
CHEMBL1644705 1 5.74
CHEMBL1644718 1 5.70
CHEMBL1644711 1 5.69
CHEMBL1644717 1 5.59
CHEMBL1644716 1 5.21
CHEMBL1644709 1 -
CHEMBL1644710 1 -
CHEMBL1644708 1 -
CHEMBL1644714 1 -
CHEMBL1644720 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1644702 IC50 = 289.0 nM 6.54
CHEMBL1644704 IC50 = 362.0 nM 6.44
CHEMBL1644703 IC50 = 413.0 nM 6.38
CHEMBL1641632 IC50 = 449.0 nM 6.35
CHEMBL1644719 IC50 = 555.0 nM 6.26
CHEMBL1644713 IC50 = 590.0 nM 6.23
CHEMBL1644706 IC50 = 623.0 nM 6.21
CHEMBL1467 ALLOPURINOL IC50 = 753.0 nM 6.12
CHEMBL1644715 IC50 = 1020.0 nM 5.99
CHEMBL1644707 IC50 = 1070.0 nM 5.97
CHEMBL1644712 IC50 = 1760.0 nM 5.75
CHEMBL1644705 IC50 = 1830.0 nM 5.74
CHEMBL1644718 IC50 = 1980.0 nM 5.70
CHEMBL1644711 IC50 = 2030.0 nM 5.69
CHEMBL1644717 IC50 = 2560.0 nM 5.59
CHEMBL1644716 IC50 = 6180.0 nM 5.21
CHEMBL1644709 IC50 - -
CHEMBL1644710 IC50 - -
CHEMBL1644708 IC50 - -
CHEMBL1644714 IC50 - -
CHEMBL1644720 IC50 - -