Assay Detail
Functional
CHEMBL1653933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB 900 clone after 72 hrs by Alamar blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.74 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467047 | — | — | 1 | 10.00 |
| CHEMBL381751 | — | — | 1 | 8.85 |
| CHEMBL466624 | — | — | 1 | 6.76 |
| CHEMBL468092 | — | — | 1 | 6.59 |
| CHEMBL443705 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467047 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL381751 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL466624 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL468092 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL443705 | — | IC50 | = | 319.0 | nM | 6.50 |