Assay Detail
Binding
CHEMBL1655210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Kidney |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.54 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53430 | — | — | 1 | 9.43 |
| CHEMBL294625 | — | — | 1 | 8.85 |
| CHEMBL299487 | — | — | 1 | 8.37 |
| CHEMBL431938 | — | — | 1 | 8.12 |
| CHEMBL56058 | — | — | 1 | 7.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53430 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL294625 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL299487 | — | Ki | = | 4.28 | nM | 8.37 |
| CHEMBL431938 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL56058 | — | Ki | = | 12.2 | nM | 7.91 |