Assay Detail
Binding
CHEMBL1655348
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Inhibition of Escherichia coli DXR
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL4091) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.14 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 7.52 |
| CHEMBL205338 | FR-900098 | — | 1 | 7.52 |
| CHEMBL204106 | — | — | 1 | 7.23 |
| CHEMBL1651835 | — | — | 1 | 7.00 |
| CHEMBL1651836 | — | — | 1 | 6.92 |
| CHEMBL1651834 | — | — | 1 | 6.51 |
| CHEMBL1651833 | — | — | 1 | 6.40 |
| CHEMBL1651832 | — | — | 1 | 6.34 |
| CHEMBL1615246 | — | — | 1 | 6.08 |
| CHEMBL574580 | 1-HYDROXY-5-PHENYLPYRIDIN-2(1H)-ONE | — | 1 | 5.85 |
| CHEMBL291727 | — | — | 1 | 5.40 |
| CHEMBL1615245 | PYRIDIN-2-YLMETHYLPHOSPHONIC ACID | — | 1 | 5.34 |
| CHEMBL54714 | — | — | 1 | 5.16 |
| CHEMBL1651840 | — | — | 1 | 5.15 |
| CHEMBL1651841 | — | — | 1 | 5.00 |
| CHEMBL1615247 | — | — | 1 | 4.80 |
| CHEMBL1651839 | — | — | 1 | - |
| CHEMBL1651838 | — | — | 1 | - |
| CHEMBL1651837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL205338 | FR-900098 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL204106 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1651835 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL1651836 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL1651834 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL1651833 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL1651832 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL1615246 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL574580 | 1-HYDROXY-5-PHENYLPYRIDIN-2(1H)-ONE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL291727 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1615245 | PYRIDIN-2-YLMETHYLPHOSPHONIC ACID | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL54714 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1651840 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL1651841 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1615247 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL1651839 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1651838 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1651837 | — | IC50 | > | 100000.0 | nM | - |