Assay Detail
Binding
CHEMBL1656379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRalpha V561D mutant by TR-FRET based LanthaScreen assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Kinase inhibition by deoxy analogues of the resorcylic lactone L-783277.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.63 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012519 | — | — | 1 | 8.62 |
| CHEMBL1651521 | — | — | 1 | 8.14 |
| CHEMBL1651523 | — | — | 1 | 7.02 |
| CHEMBL1651522 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012519 | — | IC50 | = | 2.38 | nM | 8.62 |
| CHEMBL1651521 | — | IC50 | = | 7.23 | nM | 8.14 |
| CHEMBL1651523 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1651522 | — | IC50 | = | 180.0 | nM | 6.75 |