Assay Detail
Functional
CHEMBL1656783
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Cytotoxicity against human NCI-ADR-RES expressing MDR1 cells after 48 to 72 hrs by WAT-1 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.15 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20684 | ABT-751 | 2.0 | 1 | 6.54 |
| CHEMBL1649644 | — | — | 1 | 6.52 |
| CHEMBL1649645 | — | — | 1 | 6.52 |
| CHEMBL1649615 | — | — | 1 | 6.47 |
| CHEMBL1649648 | — | — | 1 | 5.96 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20684 | ABT-751 | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1649644 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1649645 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1649615 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1649648 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 13000.0 | nM | 4.89 |