Assay Detail
Functional
CHEMBL1658180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus A/New Caledonia/20/99 (H1N1)) harboring neuraminidase I222V mutant infected in MDCK cells assessed as inhibition of viral-induced cytopathogenicity after 4 days post dose to IC50 for Influenza A virus A/New Caledonia/20/99 (H1N1)) harboring wild type neuraminidase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/New Caledonia/20/1999(H1N1)) |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.92 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 1 | 9.52 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.89 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1229 | OSELTAMIVIR | IC50 | = | 4.5 | nM | 8.35 |