Compound Detail
CHEMBL139367
PERAMIVIR ANHYDROUS 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(=O)O)C[C@H]1NC(=N)N
Basic Information
| ChEMBL ID | CHEMBL139367 |
| Name | PERAMIVIR ANHYDROUS |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XRQDFNLINLXZLB-CKIKVBCHSA-N |
| Therapeutic | ✓ Yes |
14
Targets
124
Activities
3
Assay Types
7
PK Parameters
20
Publications
3
Known Names
2
Indications
Molecular Properties
328.4
MW (Da)
-0.14
ALogP
4
HBA
6
HBD
148.5
PSA (Ų)
0.28
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2014 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Virus Diseases Influenza, Human
ATC Classification
J05AH03
peramivir
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIVIRALS FOR SYSTEMIC USE
Activity Summary
IC50 103 meas. best 10.15
Ki 11 meas. best 9.52
EC50 10 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuraminidase CHEMBL6135 | IC50 | 10.15 | 8.1877 | 0.1 | 13 |
| Influenza A virus CHEMBL613740 | IC50 | 10.1 | 8.3098 | 0.1 | 65 |
| Unchecked CHEMBL612545 | IC50 | 9.8 | 8.016 | 0.2 | 10 |
| Neuraminidase CHEMBL1667684 | IC50 | 9.52 | 8.63 | 0.3 | 2 |
| Unchecked CHEMBL612545 | Ki | 9.52 | 8.7638 | 0.3 | 8 |
| Neuraminidase CHEMBL1287610 | IC50 | 9.4 | 9.36 | 0.4 | 2 |
| Neuraminidase CHEMBL1795169 | Ki | 9.08 | 9.08 | 0.8 | 1 |
| Neuraminidase CHEMBL2051 | IC50 | 8.85 | 8.85 | 1.4 | 1 |
| Influenza A virus CHEMBL613740 | EC50 | 8.82 | 6.31 | 1.5 | 9 |
| Neuraminidase CHEMBL6015 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Influenza B virus CHEMBL613129 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Neuraminidase CHEMBL1795169 | IC50 | 8.47 | 8.47 | 3.4 | 1 |
| Neuraminidase CHEMBL3377 | IC50 | 8.3 | 8.13 | 5.0 | 2 |
| Neuraminidase CHEMBL1667686 | IC50 | 6.84 | 6.595 | 146.0 | 2 |
| unidentified influenza virus CHEMBL613128 | IC50 | 5.08 | 5.08 | 8400.0 | 1 |
| Sialidase CHEMBL5189 | IC50 | 4.4 | 4.4 | 39600.0 | 1 |
| Sialidase-2 CHEMBL3200 | Ki | 4.25 | 4.25 | 56000.0 | 1 |
| Sialidase-2 CHEMBL3200 | IC50 | 4.16 | 4.16 | 70000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 53835.15 | nM | Mus musculus |
| Cmax | 89.22 | nM | Mus musculus |
| Cmax | 30449.74 | nM | Homo sapiens |
| F | 2.5 | % | Mustela putorius furo |
| F | 2.5 | % | Rattus norvegicus |
| T1/2 | 24.0 | hr | Influenza A virus (A/WSN/1933(H1N1)) |
| T1/2 | 1.25 | hr | Influenza A virus (A/WSN/1933(H1N1)) |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine