Assay Detail
Binding
CHEMBL3820775
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Inhibition of oseltamivir-resistant Influenza A virus A/WSN/1933(H1N1) recombinant wild type neuraminidase transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/WSN/1933(H1N1)) |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 9.11 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 1 | 10.15 |
| CHEMBL3818436 | — | — | 1 | 9.52 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 9.40 |
| CHEMBL3819487 | — | — | 1 | 9.30 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 9.22 |
| CHEMBL3819617 | — | — | 1 | 9.22 |
| CHEMBL3819450 | — | — | 1 | 9.05 |
| CHEMBL3818211 | — | — | 1 | 9.00 |
| CHEMBL3819314 | — | — | 1 | 8.82 |
| CHEMBL3818553 | — | — | 1 | 8.80 |
| CHEMBL3817914 | — | — | 1 | 8.54 |
| CHEMBL3819492 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL3818436 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3819487 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3819617 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3819450 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3818211 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3819314 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3818553 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3817914 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3819492 | — | IC50 | = | 5.2 | nM | 8.28 |