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Target Snapshot

CHEMBL1287610 Target Snapshot

Neuraminidase · SINGLE PROTEIN · Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1))

78Compounds
13Assays
2Approved Drugs
91.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P03470. Use UniProt P03470 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P03470 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neuraminidase as ChEMBL target CHEMBL1287610, mapped to UniProt P03470. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neuraminidase
SINGLE PROTEIN · Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1))
As of 2026-09-14
ChEMBL target ID
CHEMBL1287610
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P03470
Neuraminidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neuraminidase is the right protein anchor across sources, using UniProt P03470 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeuraminidase
UniProt AccessionP03470
Component TypeProtein
Sequence Length453 aa

Neuraminidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Neuraminidase, mapped to UniProt P03470. Sequence length is 453 aa.

Mapped IDP03470
Review nameNeuraminidase
OrganismInfluenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1))
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5091.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2206459 10.05 IC50 0.09 Preclinical
CHEMBL139367 9.4 IC50 0.4 Approved
CHEMBL4288789 9.36 IC50 0.44 Preclinical
CHEMBL4285430 9.19 IC50 0.64 Preclinical
CHEMBL4278125 9.17 IC50 0.67 Preclinical
CHEMBL2205840 9.15 IC50 0.7 Preclinical
CHEMBL222813 9.1 IC50 0.8 Approved
CHEMBL4288995 9.05 IC50 0.9 Preclinical
CHEMBL4293261 9.03 IC50 0.94 Preclinical
CHEMBL4280263 9.0 IC50 0.99 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
8
5.5
7
6.0
6
6.5
3
7.0
16
7.5
7
8.0
13
8.5
14
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PERAMIVIR ANHYDROUS
CHEMBL139367
Approved 2014
ZANAMIVIR
CHEMBL222813
Approved 1999
Assay Landscape

Assay Landscape

13
Total Assays
70
Tested Compounds
1
Assay Types
Binding — 13 assays, 70 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 8 47 7.5
cell-based format 3 23 8.0
organism-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine