Assay Detail
Functional
CHEMBL1658505
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Antimalarial activity against Plasmodium falciparum assessed as parasite growth inhibition after 48 hrs by [3H]hypoxanthin incorporation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.05 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 9.02 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.17 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 8.08 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.73 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL170 | QUININE | IC50 | = | 53.7 | nM | 7.27 |