Assay Detail
Functional
CHEMBL1658766
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Cytotoxicity against human CEM cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10-diones: Synthesis and anti-proliferative characteristics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.09 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.22 |
| CHEMBL1652383 | — | — | 1 | 6.82 |
| CHEMBL469321 | — | — | 1 | 6.40 |
| CHEMBL1652384 | — | — | 1 | 6.36 |
| CHEMBL1652385 | — | — | 1 | 6.13 |
| CHEMBL469319 | — | — | 1 | 5.96 |
| CHEMBL1652382 | — | — | 1 | 5.92 |
| CHEMBL1652386 | — | — | 1 | 5.82 |
| CHEMBL1652387 | — | — | 1 | 5.78 |
| CHEMBL1652388 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1652383 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL469321 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1652384 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1652385 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL469319 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1652382 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1652386 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1652387 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL1652388 | — | IC50 | = | 35000.0 | nM | 4.46 |