Assay Detail
Functional
CHEMBL1658789
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Cytotoxicity against human KB/VCR cells after 72 hrs by MTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB/VCR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new 4β-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.30 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1652391 | — | — | 1 | 8.90 |
| CHEMBL1652392 | — | — | 1 | 8.81 |
| CHEMBL1652390 | — | — | 1 | 8.80 |
| CHEMBL1652399 | — | — | 1 | 8.75 |
| CHEMBL1652396 | — | — | 1 | 8.73 |
| CHEMBL1652397 | — | — | 1 | 8.68 |
| CHEMBL1652395 | — | — | 1 | 8.66 |
| CHEMBL1652400 | — | — | 1 | 8.66 |
| CHEMBL1652401 | — | — | 1 | 8.63 |
| CHEMBL1652413 | — | — | 1 | 8.55 |
| CHEMBL1652486 | — | — | 1 | 8.51 |
| CHEMBL1652389 | — | — | 1 | 8.46 |
| CHEMBL1652411 | — | — | 1 | 8.43 |
| CHEMBL1652398 | — | — | 1 | 8.41 |
| CHEMBL1652394 | — | — | 1 | 8.40 |
| CHEMBL1652405 | — | — | 1 | 8.29 |
| CHEMBL1652412 | — | — | 1 | 8.28 |
| CHEMBL1652408 | — | — | 1 | 8.28 |
| CHEMBL1652487 | — | — | 1 | 8.24 |
| CHEMBL1652403 | — | — | 1 | 8.19 |
| CHEMBL1652404 | — | — | 1 | 8.13 |
| CHEMBL1652409 | — | — | 1 | 8.07 |
| CHEMBL1652407 | — | — | 1 | 8.03 |
| CHEMBL1652406 | — | — | 1 | 8.02 |
| CHEMBL1652488 | — | — | 1 | 7.88 |
| CHEMBL1652410 | — | — | 1 | 7.86 |
| CHEMBL1652490 | — | — | 1 | 7.85 |
| CHEMBL1652393 | — | — | 1 | 7.72 |
| CHEMBL1652402 | — | — | 1 | 7.57 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1652391 | — | IC50 | = | 1.27 | nM | 8.90 |
| CHEMBL1652392 | — | IC50 | = | 1.53 | nM | 8.81 |
| CHEMBL1652390 | — | IC50 | = | 1.57 | nM | 8.80 |
| CHEMBL1652399 | — | IC50 | = | 1.78 | nM | 8.75 |
| CHEMBL1652396 | — | IC50 | = | 1.85 | nM | 8.73 |
| CHEMBL1652397 | — | IC50 | = | 2.09 | nM | 8.68 |
| CHEMBL1652395 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1652400 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1652401 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL1652413 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1652486 | — | IC50 | = | 3.08 | nM | 8.51 |
| CHEMBL1652389 | — | IC50 | = | 3.44 | nM | 8.46 |
| CHEMBL1652411 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1652398 | — | IC50 | = | 3.87 | nM | 8.41 |
| CHEMBL1652394 | — | IC50 | = | 3.95 | nM | 8.40 |
| CHEMBL1652405 | — | IC50 | = | 5.08 | nM | 8.29 |
| CHEMBL1652412 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1652408 | — | IC50 | = | 5.31 | nM | 8.28 |
| CHEMBL1652487 | — | IC50 | = | 5.72 | nM | 8.24 |
| CHEMBL1652403 | — | IC50 | = | 6.51 | nM | 8.19 |
| CHEMBL1652404 | — | IC50 | = | 7.39 | nM | 8.13 |
| CHEMBL1652409 | — | IC50 | = | 8.48 | nM | 8.07 |
| CHEMBL1652407 | — | IC50 | = | 9.28 | nM | 8.03 |
| CHEMBL1652406 | — | IC50 | = | 9.55 | nM | 8.02 |
| CHEMBL1652488 | — | IC50 | = | 13.06 | nM | 7.88 |
| CHEMBL1652410 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL1652490 | — | IC50 | = | 14.21 | nM | 7.85 |
| CHEMBL1652393 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL1652402 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 83.4 | nM | 7.08 |
| CHEMBL1652489 | — | IC50 | > | 50.0 | nM | - |