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Assay Detail

CHEMBL1658791

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human 95-D cells after 72 hrs by MTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type 95-D
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and biological evaluation of new 4β-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents.
Wang L, Yang F, Yang X, Guan X, Hu C, Liu T, He Q, Yang B, Hu Y.
Eur J Med Chem (2011) 46 : 285 -296
PubMed 21145139 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 8.47 10.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1652390 1 10.44
CHEMBL1652389 1 9.70
CHEMBL1652412 1 9.39
CHEMBL1652409 1 9.38
CHEMBL1652407 1 9.36
CHEMBL1652404 1 9.26
CHEMBL1652408 1 8.97
CHEMBL1652411 1 8.94
CHEMBL1652396 1 8.93
CHEMBL1652486 1 8.91
CHEMBL1652413 1 8.90
CHEMBL1652487 1 8.78
CHEMBL1652410 1 8.47
CHEMBL1652403 1 8.38
CHEMBL1652488 1 8.18
CHEMBL1652399 1 8.13
CHEMBL1652392 1 8.01
CHEMBL1652395 1 8.00
CHEMBL1652391 1 7.94
CHEMBL1652405 1 7.92
CHEMBL1652398 1 7.84
CHEMBL1652397 1 7.83
CHEMBL1652489 1 7.80
CHEMBL1652394 1 7.77
CHEMBL1652393 1 7.76
CHEMBL1652490 1 7.71
CHEMBL44657 ETOPOSIDE 4.0 1 7.70
CHEMBL1652406 1 7.69
CHEMBL1652401 1 7.59
CHEMBL1652400 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1652390 IC50 = 0.036 nM 10.44
CHEMBL1652389 IC50 = 0.2 nM 9.70
CHEMBL1652412 IC50 = 0.41 nM 9.39
CHEMBL1652409 IC50 = 0.42 nM 9.38
CHEMBL1652407 IC50 = 0.44 nM 9.36
CHEMBL1652404 IC50 = 0.55 nM 9.26
CHEMBL1652408 IC50 = 1.08 nM 8.97
CHEMBL1652411 IC50 = 1.15 nM 8.94
CHEMBL1652396 IC50 = 1.17 nM 8.93
CHEMBL1652486 IC50 = 1.23 nM 8.91
CHEMBL1652413 IC50 = 1.25 nM 8.90
CHEMBL1652487 IC50 = 1.66 nM 8.78
CHEMBL1652410 IC50 = 3.41 nM 8.47
CHEMBL1652403 IC50 = 4.13 nM 8.38
CHEMBL1652488 IC50 = 6.56 nM 8.18
CHEMBL1652399 IC50 = 7.4 nM 8.13
CHEMBL1652392 IC50 = 9.84 nM 8.01
CHEMBL1652395 IC50 = 10.0 nM 8.00
CHEMBL1652391 IC50 = 11.5 nM 7.94
CHEMBL1652405 IC50 = 12.04 nM 7.92
CHEMBL1652398 IC50 = 14.6 nM 7.84
CHEMBL1652397 IC50 = 14.8 nM 7.83
CHEMBL1652489 IC50 = 15.7 nM 7.80
CHEMBL1652394 IC50 = 17.1 nM 7.77
CHEMBL1652393 IC50 = 17.2 nM 7.76
CHEMBL1652490 IC50 = 19.6 nM 7.71
CHEMBL44657 ETOPOSIDE IC50 = 20.2 nM 7.70
CHEMBL1652406 IC50 = 20.3 nM 7.69
CHEMBL1652401 IC50 = 25.8 nM 7.59
CHEMBL1652400 IC50 > 50.0 nM -
CHEMBL1652402 IC50 > 50.0 nM -