Assay Detail
Functional
CHEMBL1658846
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Antiviral activity against HSV1 PAA5 harboring polymerase R842S mutant gene infected in HFF after 3 days by plaque reduction assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.26 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 7.96 |
| CHEMBL1631219 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1631219 | — | EC50 | = | 28000.0 | nM | 4.55 |