Assay Detail
Functional
CHEMBL1659934
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Antiviral activity against HIV1 LAI infected in human MT2 cells by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.87 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571882 | — | — | 1 | 8.70 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.52 |
| CHEMBL577560 | — | — | 1 | 8.40 |
| CHEMBL1650599 | — | — | 1 | 7.85 |
| CHEMBL571982 | — | — | 1 | 7.66 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.62 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.41 |
| CHEMBL222559 | TIPRANAVIR | 4.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571882 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL577560 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1650599 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL571982 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL222559 | TIPRANAVIR | EC50 | = | 170.0 | nM | 6.77 |