Assay Detail
Functional
CHEMBL1660956
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Antiviral activity against HCV1B BM4-5 infected in human Huh7.5 cells assessed as decrease in intracellular viral RNA treated for 3 days measured 24 hrs after last dose by luciferase reporter gene-based blot hybridization
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.48 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487297 | — | — | 1 | 5.88 |
| CHEMBL472584 | — | — | 1 | 5.70 |
| CHEMBL1652266 | — | — | 1 | 5.17 |
| CHEMBL1652261 | — | — | 1 | 5.16 |
| CHEMBL286534 | — | — | 1 | - |
| CHEMBL1652265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487297 | — | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL472584 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL1652266 | — | EC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL1652261 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL286534 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1652265 | — | EC50 | > | 100000.0 | nM | - |