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Compound Detail

CHEMBL487297

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CCCCCCCCCCCCCCCCCCOCCOP(=O)(O)CO[C@H](CO)Cn1cnc2c(N)ncnc21

Basic Information

ChEMBL ID CHEMBL487297
Phase Preclinical
Structure Type MOL
InChI Key HMMRNEAGFOALKT-SANMLTNESA-N
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names

Molecular Properties

599.8
MW (Da)
6.22
ALogP
10
HBA
3
HBD
154.8
PSA (Ų)
0.08
QED
2
Ro5 Violations
27
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H54N5O6P
MW 599.75
Aromatic Rings 2
Heavy Atoms 41
NP-Likeness 0.07

Activity Summary

EC50 7 meas. best 8.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vaccinia virus
CHEMBL613493
EC50 8.0 7.5 10.0 2
Cowpox virus
CHEMBL612672
EC50 7.7 7.7 20.0 1
BK polyomavirus
CHEMBL4888480
EC50 7.52 7.52 30.0 1
Hepatitis B virus
CHEMBL613497
EC50 7.12 7.12 76.0 1
Hepatitis C virus
CHEMBL379
EC50 6.16 6.02 690.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine