Assay Detail
Functional
CHEMBL997977
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Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction of viral replication after 3 days
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.45 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472584 | — | — | 1 | 8.00 |
| CHEMBL487297 | — | — | 1 | 8.00 |
| CHEMBL203321 | BRINCIDOFOVIR | 4.0 | 1 | 6.10 |
| CHEMBL286534 | — | — | 1 | 5.57 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472584 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL487297 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL203321 | BRINCIDOFOVIR | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL286534 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 26000.0 | nM | 4.58 |