Assay Detail
Functional
CHEMBL997975
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Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction of viral replication after 3 days
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cowpox virus (Brighton Red) |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.30 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472584 | — | — | 1 | 7.70 |
| CHEMBL487297 | — | — | 1 | 7.70 |
| CHEMBL203321 | BRINCIDOFOVIR | 4.0 | 1 | 6.22 |
| CHEMBL286534 | — | — | 1 | 5.40 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472584 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL487297 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL203321 | BRINCIDOFOVIR | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL286534 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 35000.0 | nM | 4.46 |