Assay Detail

CHEMBL1661048

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against Human coxsackievirus A16 (strain G-10) A16 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human coxsackievirus A16 (strain G-10)
Cell Type	Vero
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.

De Palma AM, Thibaut HJ, van der Linden L, Lanke K, Heggermont W, Ireland S, Andrews R, Arimilli M, Al-Tel TH, De Clercq E, van Kuppeveld F, Neyts J.
Antimicrob Agents Chemother (2009) 53 : 1850 -1857
PubMed 19237651 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.50	6.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL283403	ENVIROXIME	2.0	1	6.92
CHEMBL1163676	—	—	1	6.07

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL283403	ENVIROXIME	EC50	=	120.0	nM	6.92
CHEMBL1163676	—	EC50	=	850.0	nM	6.07