Assay Detail
Functional
CHEMBL1661808
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Antiviral activity against enfuvirtide-resistant Human immunodeficiency virus 1 NL4-3 by MAGI assay using human HeLa Cd4/LTR-beta-galactosidase cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.86 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2414506 | — | — | 1 | 8.80 |
| CHEMBL1651959 | — | — | 1 | 8.64 |
| CHEMBL525781 | — | — | 1 | 8.62 |
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 7.82 |
| CHEMBL524513 | — | — | 1 | 6.66 |
| CHEMBL1651961 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2414506 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1651959 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL525781 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL525076 | ENFUVIRTIDE | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL524513 | — | EC50 | = | 217.0 | nM | 6.66 |
| CHEMBL1651961 | — | EC50 | = | 245.0 | nM | 6.61 |