Assay Detail
Functional
CHEMBL1662358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I8T mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coxsackievirus B3 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.64 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283403 | ENVIROXIME | 2.0 | 1 | 6.16 |
| CHEMBL1652130 | — | — | 1 | 5.54 |
| CHEMBL1163676 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283403 | ENVIROXIME | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1652130 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1163676 | — | EC50 | = | 6000.0 | nM | 5.22 |