Assay Detail
Binding
CHEMBL1663403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DHODH in Wistar rat liver homogenates by DCIP reduction assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL2383) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1,2,5-Oxadiazole analogues of leflunomide and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.20 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 7.70 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 5.80 |
| CHEMBL1651801 | — | — | 1 | 4.77 |
| CHEMBL1651809 | — | — | 1 | 4.58 |
| CHEMBL1651789 | — | — | 1 | 4.22 |
| CHEMBL1651807 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1651801 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1651809 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1651789 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1651807 | — | IC50 | = | 74000.0 | nM | 4.13 |