Assay Detail
Functional
CHEMBL1663695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antibiofilm activity in Salmonella Typhimurium ATCC 14028 assessed as inhibition of biofilm formation at 37 degC after 24 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Salmonella typhimurium (CHEMBL351) ↗| Type | ORGANISM |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
Publication
Structure-activity relationship of 4(5)-aryl-2-amino-1H-imidazoles, N1-substituted 2-aminoimidazoles and imidazo[1,2-a]pyrimidinium salts as inhibitors of biofilm formation by Salmonella typhimurium and Pseudomonas aeruginosa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.39 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1649772 | — | — | 1 | 4.52 |
| CHEMBL1649773 | — | — | 1 | 4.26 |
| CHEMBL1649757 | — | — | 1 | - |
| CHEMBL1649771 | — | — | 1 | - |
| CHEMBL1649774 | — | — | 1 | - |
| CHEMBL1649775 | — | — | 1 | - |
| CHEMBL1649776 | — | — | 1 | - |
| CHEMBL1649777 | — | — | 1 | - |
| CHEMBL1649778 | — | — | 1 | - |
| CHEMBL1649779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1649772 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL1649773 | — | IC50 | = | 54300.0 | nM | 4.26 |
| CHEMBL1649757 | — | IC50 | = | 146400.0 | nM | - |
| CHEMBL1649771 | — | IC50 | = | 238400.0 | nM | - |
| CHEMBL1649774 | — | IC50 | = | 395700.0 | nM | - |
| CHEMBL1649775 | — | IC50 | - | — | - | |
| CHEMBL1649776 | — | IC50 | - | — | - | |
| CHEMBL1649777 | — | IC50 | - | — | - | |
| CHEMBL1649778 | — | IC50 | = | 348900.0 | nM | - |
| CHEMBL1649779 | — | IC50 | - | — | - |