Assay Detail
Functional
CHEMBL1663717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiprotozoal activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB900 by alamar blue assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.49 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242102 | — | — | 1 | 7.16 |
| CHEMBL1650072 | — | — | 1 | 6.50 |
| CHEMBL1650074 | — | — | 1 | 6.43 |
| CHEMBL1650071 | — | — | 1 | 6.14 |
| CHEMBL1650070 | — | — | 1 | 6.08 |
| CHEMBL1650073 | — | — | 1 | 5.93 |
| CHEMBL1650075 | — | — | 1 | 4.96 |
| CHEMBL1650079 | — | — | 1 | 4.83 |
| CHEMBL1650078 | — | — | 1 | 4.21 |
| CHEMBL1650077 | — | — | 1 | 4.13 |
| CHEMBL1650076 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242102 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1650072 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1650074 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1650071 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1650070 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1650073 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL1650075 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL1650079 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL1650078 | — | IC50 | = | 61300.0 | nM | 4.21 |
| CHEMBL1650077 | — | IC50 | = | 73800.0 | nM | 4.13 |
| CHEMBL1650076 | — | IC50 | = | 86700.0 | nM | 4.06 |