Assay Detail
ADMET
CHEMBL1663723
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Cytotoxicity against rat L6 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.40 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650072 | — | — | 1 | 4.96 |
| CHEMBL1650073 | — | — | 1 | 4.70 |
| CHEMBL1650071 | — | — | 1 | 4.40 |
| CHEMBL1650075 | — | — | 1 | 4.28 |
| CHEMBL1650070 | — | — | 1 | 4.27 |
| CHEMBL1650079 | — | — | 1 | 4.17 |
| CHEMBL1650074 | — | — | 1 | 4.04 |
| CHEMBL242102 | — | — | 1 | - |
| CHEMBL1650076 | — | — | 1 | - |
| CHEMBL1650077 | — | — | 1 | - |
| CHEMBL1650078 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650072 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1650073 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1650071 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1650075 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL1650070 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL1650079 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL1650074 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL242102 | — | IC50 | = | 212000.0 | nM | - |
| CHEMBL1650076 | — | IC50 | > | 102000.0 | nM | - |
| CHEMBL1650077 | — | IC50 | > | 124000.0 | nM | - |
| CHEMBL1650078 | — | IC50 | > | 107000.0 | nM | - |