Assay Detail
Functional
CHEMBL1664565
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Antiviral activity against influenza A (A/Montana/02/2009 (H1N1)) virus harboring neuraminidase H275Y mutant after 30 mins by NA-star substrate based chemiluminescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.54 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466246 | LANINAMIVIR | 2.0 | 1 | 9.47 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 9.38 |
| CHEMBL473062 | — | — | 1 | 9.00 |
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 1 | 7.83 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466246 | LANINAMIVIR | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL473062 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL139367 | PERAMIVIR ANHYDROUS | IC50 | = | 14.96 | nM | 7.83 |
| CHEMBL1229 | OSELTAMIVIR | IC50 | = | 99.57 | nM | 7.00 |