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Assay Detail

CHEMBL1664624

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant LyP assessed as hydrolysis of DiFMUP
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 22 (CHEMBL2889)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Vang T, Xie Y, Liu WH, Vidović D, Liu Y, Wu S, Smith DH, Rinderspacher A, Chung C, Gong G, Mustelin T, Landry DW, Rickert RC, Schürer SC, Deng SX, Tautz L.
J Med Chem (2011) 54 : 562 -571
PubMed 21190368 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 5.93 6.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1650888 1 6.57
CHEMBL1650889 1 6.47
CHEMBL1650890 1 6.47
CHEMBL1650891 1 6.42
CHEMBL1650892 1 6.39
CHEMBL1649599 1 6.32
CHEMBL1650893 1 6.28
CHEMBL1650894 1 6.25
CHEMBL1650895 1 6.21
CHEMBL1650896 1 6.19
CHEMBL1650897 1 6.19
CHEMBL1650898 1 6.19
CHEMBL1650899 1 6.15
CHEMBL1650900 1 6.13
CHEMBL1650901 1 6.11
CHEMBL1650902 1 6.05
CHEMBL1650903 1 6.04
CHEMBL1650904 1 6.01
CHEMBL1650905 1 5.96
CHEMBL1650906 1 5.93
CHEMBL1650907 1 5.87
CHEMBL1650908 1 5.83
CHEMBL1650909 1 5.75
CHEMBL1650910 1 5.70
CHEMBL1650911 1 5.66
CHEMBL1650912 1 5.63
CHEMBL1650913 1 5.58
CHEMBL1650914 1 5.51
CHEMBL1650915 1 5.49
CHEMBL1650916 1 5.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1650888 IC50 = 270.0 nM 6.57
CHEMBL1650889 IC50 = 340.0 nM 6.47
CHEMBL1650890 IC50 = 340.0 nM 6.47
CHEMBL1650891 IC50 = 380.0 nM 6.42
CHEMBL1650892 IC50 = 410.0 nM 6.39
CHEMBL1649599 IC50 = 480.0 nM 6.32
CHEMBL1650893 IC50 = 520.0 nM 6.28
CHEMBL1650894 IC50 = 560.0 nM 6.25
CHEMBL1650895 IC50 = 610.0 nM 6.21
CHEMBL1650896 IC50 = 640.0 nM 6.19
CHEMBL1650897 IC50 = 650.0 nM 6.19
CHEMBL1650898 IC50 = 650.0 nM 6.19
CHEMBL1650899 IC50 = 710.0 nM 6.15
CHEMBL1650900 IC50 = 740.0 nM 6.13
CHEMBL1650901 IC50 = 770.0 nM 6.11
CHEMBL1650902 IC50 = 900.0 nM 6.05
CHEMBL1650903 IC50 = 910.0 nM 6.04
CHEMBL1650904 IC50 = 970.0 nM 6.01
CHEMBL1650905 IC50 = 1110.0 nM 5.96
CHEMBL1650906 IC50 = 1180.0 nM 5.93
CHEMBL1650907 IC50 = 1350.0 nM 5.87
CHEMBL1650908 IC50 = 1490.0 nM 5.83
CHEMBL1650909 IC50 = 1800.0 nM 5.75
CHEMBL1650910 IC50 = 2010.0 nM 5.70
CHEMBL1650911 IC50 = 2210.0 nM 5.66
CHEMBL1650912 IC50 = 2350.0 nM 5.63
CHEMBL1650913 IC50 = 2640.0 nM 5.58
CHEMBL1650914 IC50 = 3100.0 nM 5.51
CHEMBL1650915 IC50 = 3220.0 nM 5.49
CHEMBL1650916 IC50 = 3440.0 nM 5.46
CHEMBL1650917 IC50 = 3840.0 nM 5.42
CHEMBL260920 IC50 = 4500.0 nM 5.35
CHEMBL1650918 IC50 = 4860.0 nM 5.31
CHEMBL1650919 IC50 = 5020.0 nM 5.30
CHEMBL1650920 IC50 = 6200.0 nM 5.21