Assay Detail
Functional
CHEMBL1664693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 isolate 92US657 infected in human MT2 cells assessed as inhibition viral p24 antigen production after 4 days by ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological activity of novel 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.72 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650931 | — | — | 1 | 6.50 |
| CHEMBL1650934 | — | — | 1 | 6.50 |
| CHEMBL1650935 | — | — | 1 | 6.32 |
| CHEMBL583135 | — | — | 1 | 6.28 |
| CHEMBL1650933 | — | — | 1 | 6.06 |
| CHEMBL1650932 | — | — | 1 | 6.00 |
| CHEMBL575309 | — | — | 1 | 5.97 |
| CHEMBL1650930 | — | — | 1 | 5.82 |
| CHEMBL1650921 | — | — | 1 | 5.66 |
| CHEMBL227675 | — | — | 1 | 5.62 |
| CHEMBL1650927 | — | — | 1 | 5.56 |
| CHEMBL1650929 | — | — | 1 | 5.53 |
| CHEMBL1650928 | — | — | 1 | 5.46 |
| CHEMBL1650924 | — | — | 1 | 5.38 |
| CHEMBL1650926 | — | — | 1 | 5.33 |
| CHEMBL1650923 | — | — | 1 | 5.23 |
| CHEMBL1650922 | — | — | 1 | 5.09 |
| CHEMBL1650925 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650931 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1650934 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1650935 | — | EC50 | = | 477.0 | nM | 6.32 |
| CHEMBL583135 | — | EC50 | = | 521.0 | nM | 6.28 |
| CHEMBL1650933 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1650932 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL575309 | — | EC50 | = | 1075.0 | nM | 5.97 |
| CHEMBL1650930 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1650921 | — | EC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL227675 | — | EC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL1650927 | — | EC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL1650929 | — | EC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL1650928 | — | EC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL1650924 | — | EC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL1650926 | — | EC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL1650923 | — | EC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL1650922 | — | EC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL1650925 | — | EC50 | = | 20830.0 | nM | 4.68 |